VISPRIL TABLETS
LISINOPRIL TABLETS BP 10 MG
- Each uncoated tablet contains:
- Lisinopril Dihydrate BP
- Eq. to Lisinopril 10 mg
- Excipients Q.S.
DRUG DESCRIPTION
Vispril is an oral long-acting angiotensin converting enzyme (ACE) inhibitor. Vispril used to treat high blood pressure (hypertension), congestive heart failure, and to improve survival after a heart attack.
INDICATIONS VISPRIL IS USED
- To treat a condition known as symptomatic heart failure where the heart no longer pumps blood as effectively as it should
- To treat high blood pressure
- To help prevent any more heart problems in patients who have recently had a heart attack
- To treat kidney disease resulting from diabetes and high blood pressure.
- Lisinopril is recommended in children (above 6 years old) only for the treatment of high blood pressure (hypertension).
PHARMACOLOGICAL ACTIONS MECHANISM OF ACTION
Lisinopril works by widening blood vessels, which helps reduce blood pressure and makes it easier for heart to pump blood to all parts of body.
PHARMACOKINETICS ABSORPTION
Following oral administration of Vispril, peak serum concentrations occur within about 7 hours, although there was a trend to a small delay in time taken to reach peak serum concentrations in acute myocardial infarction patients. Based on urinary recovery, the mean extent of absorption of lisinopril is approximately 25% with inter-patient variability of 6-60% over the dose range studied (5-80mg).
The absolute bioavailability is reduced approximately 16% in patients with heart failure. Lisinopril absorption is not affected by the presence of food.
The absolute bioavailability is reduced approximately 16% in patients with heart failure. Lisinopril absorption is not affected by the presence of food.
DISTRIBUTION
Lisinopril does not appear to be bound to serum proteins other than to circulating angiotensin converting enzyme (ACE). Studies in rats indicate that lisinopril crosses the blood-brain barrier poorly.
ELIMINATION
Lisinopril does not undergo metabolism and is excreted entirely unchanged into the urine. On multiple dosing lisinopril has an effective half-life of accumulation of 12.6 hours. The clearance of lisinopril in healthy subjects is approximately 50 ml/min.
CONTRAINDICATIONS
- Hypersensitivity to the active substance or to any of the excipients or any other angiotensin converting enzyme (ACE) inhibitor.
- History of angioedema associated with previous ACE inhibitor therapy.
- Hereditary or idiopathic angioedema.
PREGNANY & LACATION PREGNANCY
The use of Vispril is not recommended during the first trimester of pregnancy. The use of Vispril is contraindicated during the second and third trimester of pregnancy.
LACTATION
Because no information is available regarding the use of Lisinopril during breastfeeding, Lisinopril is not recommended and alternative treatments with better established safety profiles during breast-feeding are preferable, especially while nursing a newborn or preterm infant.
DOSAGE & ROUTE OF ADMINISTRATION
In patients with hypertension the usual recommended starting dose is 10 mg. The dosage may be titrated upward until blood pressure is controlled or to a maximum of 40 mg daily,OR as directed by a physician.
SIDE-EFFECTS
- Dizziness, Headache, Cough, Diarrhoea, Vomiting etc.
DRUG INTERACTION
- Lithium, Potassium Supplements, Diuretics.
OVER DOSAGE
- Limited data are available for overdose in humans. The recommended treatment of overdose is intravenous infusion of normal saline solution.
PRESENTATION
- 1 x 10 tablets Alu-Alu in a Mono Pack.
STORAGE INSTRUCTIONS
- Store below 25˚C, Protect from light.
- KEEP OUT OF REACH OF CHILDREN.
