POVIDONE IODINE SOLUTION 10% W/V USP

DESCRIPTION

Povidone Iodine 10% Solution is an antiseptic medicine used to prevent and treat minor wounds and skin infections. It kills sensitive organisms like bacteria, fungus, protozoa, and spores present on the skin. It is also used to sanitize skin before a surgical procedure is performed.

COMPOSITION

Povidone Iodine USP	10 % w/v
Available Iodine	1% w/v
Aqueous Base	Q.S.

PHARMACOLOGY

Mechanism of Action
Povidone iodine is an iodophore antiseptic and is a microbicidal drug. It releases iodine from its complex and produces pharmacological actions. The released iodine produces antiseptic actions. Iodine is highly reactive with surrounding and has strong oxidizing effect on functional groups of amino acids (-NH 2, -SH etc.), Nucleotides, and fatty acids (double bond of unsaturated fatty acids). Interaction of Iodine with these groups in a cell results in disintegration of the cytoplasm, enzyme denaturation, loss of integrity in the bacterial cell membrane and fungal cell wall .These will leads to destruction of microbial protein and DNA and finally kills the microbes.

PHARMACOKINETICS

Absorption : It is poorly absorbed through intact skin but absorption is enhanced through denuded skin.
Distribution : Povidone-Iodine is intended for topical application and has no volume of distribution.
Metabolism : Povidone-Iodine is not absorbed or metabolized.
Excretion : Povidone-Iodine is intended for topical application and is not eliminated.

INDICATIONS

Oral infections : Povidone Iodine 10% Solution is used for the prevention and treatment of infections in the mouth.
Minor wounds : Povidone Iodine 10% Solution is used for the prevention and treatment of skin infection on the skin. It is used as an antiseptic and first aid for minor cuts, grazes, abrasions, and blisters.
Vaginal Candidiasis : Povidone Iodine 10% Solution is also used to prevent and treat the fungal infection of the vagina. It may be used in combination with other medicines for better results.
Skin disinfectant : Povidone Iodine 10% Solution is also used to clean a patient’s skin before a surgical procedure is performed.

CONTRAINDICATIONS

To be applied undiluted in preoperative skin disinfection and general antiseptic. This solution is for external use only.

OVERDOSE

Contact a doctor if you have used too much of povidone iodine or have accidently swallowed the medicine. Symptoms of overdose may include a metallic taste in the mouth, increased salivation, burning or pain sensation in the mouth or throat, diarrhea etc. Immediate medical intervention may be needed if the overdose is severe.

WARNING

Severe skin allergy : Use of this medicine should be discontinued if you experience a skin rash, hive, or severe itching.
External use only : This medicine is for external use only and should not be applied in the eyes.
Short-term use : This medicine should be used for short duration only as the risk of side effects increase significantly on prolonged usage.
Kidney disease : This medicine should be used with caution in patients having a kidney disease or an impairment of the normal kidney function.
Deep wounds : This medicine should not be used when the wound is very deep or puncture wounds.
Burns : This medicine should not be used in case of serious burns.

DRUG INTERACTION

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

INTERACTION WITH ALCOHOL

DISEASE INTERACTIONS

This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.