IBUPROFEN AND PARACETAMOL ORAL SUSPENSION (FEXOFEN)

COMPOSITION:

Each 5ml contains:

Ibuprofen  BP              100mg

Paracetamol  BP          125mg

Flavoured suspension base        Q.S

DOSAGE AND ADMINSTRATION

Age group                                      Dosage

3-1 year          2-25ml three to four times daily

1-4 year         4-4.5ml three to four times daily

4-7 years       4-8ml three to four times daily

7-10 years    8-10ml three to four times daily

10-12 ears      8-15ml three to four times daily

SYMOPTOMS

Most patients who have ingested clinically important amounts of NSAIDS ,will develop no more than nausea ,vomiting, epigastric pain, abdominal pain or more rarely diarrhoea. Tinnitus, headache, gastrointestinal bleeding are also possible. In more serious poisoning, toxicity is seen in the central nervous system, manifesting as lethargy or drowsiness, occasionally excitation and disorientation or coma. Occasional patients develop convulsions.

In serious poisoning metabolic acidosis may occur and the prothrombin time/INR may be prolonged, probably due to interference with the actions of circulating clotting factors. Acute renal failure and liver damage may occur. Exacerbation of  asthma is possible in  asthmatics. Rhabdomyolysis, Hypotension, bradycardia, tachycradia and atrial fibrillation have also been reported. the onset of symptoms usually occurs within 4 hours.